Our research is focused on neurodegenerative and neuromuscular disorders such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). The central thematic of our research is to identify novel pathological pathways that contribute to the pathophysiology of these diseases and to investigate therapeutic strategies to correct the identified defects.
Our current projects are:
Investigating the pathogenic role of the TWEAK/Fn14 in denervation-induced muscular atrophy in ALS and SMA.
Performing a comprehensive analysis of metabolic and circadian perturbations in SMA and ALS.
Investigating the role of brown adipose tissue in SMA pathogenesis.
Developing combinatorial therapeutic approaches for SMA therapy.
Current and past research in the Bowerman lab funded by: